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Join the Community: Learn how different classes of If you're a visual learner struggling to remember key facts about Official Ninja Nerd Website: Ninja Nerds! In this pharmacology lecture, Professor Zach Murphy provides a ... Penicillin pass through porins of gram negative bacterial cell wall. The penicillin then binds to penicillin binding protein linked the ... Vancomycin affects mainly gram positive bacteria. Gram positive bacteria have thick peptidoglycan layer in their cell wall. For example they can disturb the cell wall synthesis this is wall inhibitors include the beta lactams